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D75.81 Myelofibrosis Myelofibrosis is a rare type of blood cancer in which the bone marrow (the soft, spongy tissue inside most bones) is replaced by fibrous scar tissue. It is considered a form of chronic leukemia . When myelofibrosis occurs on its own, it is called primary myelofibrosis . If it occurs as the result of a separate disease, it is known as secondary myelofibrosis (e.g. scar tissue in the bone marrow as a complication of an autoimmune disease). The bone marrow contains immature blood-forming cells that may develop into three types of specialized blood cells: red blood cells, white blood cells, or platelets. When a change (mutation) occurs in the DNA of a single cell, the mutation will be passed on to new cells when the defective cell divides. As time goes by, more and more abnormal cells are produced. They can also gain additional mutations making the cancer cells more aggressive over ...